Outstanding discoveries begin with Stem Pharm Human Neural Organoids

Stem Pharm’s human neural organoids are an advanced in vitro platform for neurological drug discovery. Cell-type diverse, the organoids are composed of neurons, astrocytes, vascular cells and feature microglia, the brain’s resident immune cells. These physiologically relevant organoids enable the study of neuroinflammation and can model features of human neurodegeneration not observed in rodent models, making them a superior platform for neuro-immune drug discovery research.

 Optimized for Drug Discovery

Organoid Features:

  • Derived from human iPSCs

  • Unique morphology confers biolologic and assay advantages

  • Scalable 96-well plate format

  • Viable long-term without necrosis

  • Compatible with advanced readouts for pathway analysis, target identification  and phenotypic drug screening

  • Versatile – can introduce other cells and biologics for disease modeling and screening

Applications:

  • Neuroinflammation

  • Neurodegenerative diseases

  • Brain trauma

  • Brain cancers

  • Epilepsy

  • Stroke

  • Genetic CNS diseases

  • Neurodevelopment

  • Neurotoxicity

Ask us about our case studies - Neuroinflammation, Alzheimer’s Disease, Glioblastoma, Developmental Neurotoxicity

Validated and Reproducible Biology

Diverse, highly reproducible cellular microenvironment extensively characterized by bulk and single cell transcriptomics

Incorporated organoid microglia resemble human in vivo microglia and respond appropriately to pro- and anti-inflammatory stimuli

Red (Iba1) Microglia, Blue (Hoechst) Nuclei

Multiple Assay Readouts

to generate insights into disease biology and target selection

Transcriptomic Analysis

Bulk and Single Cell RNAseq

Perturbations

3D Imaging

Immunofluorescence, Confocal

Immunoassay

Cytokine, Chemokine

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

Schwartz et al. (2015)

Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques

Barry et al. (2017)